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miRNAs play a role in cardiovascular disease, and in particular in ischaemic pathology. It has been observed that during cardiac ischaemia there are defined patterns of miRNA expression, including the re-expression of fetal genes, which are normally only expressed in early stages of heart development.
We now know that some miRNAs are involved in the generation of heart failure after myocardial infarction, the appearance of various types of arrhythmias, as well as in various congenital heart diseases, while other miRNAs are associated with fibrosis and related to ventricular remodelling.
Therefore, under this idea, we have selected circulating miRNAs whose altered levels in serum/plasma of patients may be related to the risk of suffering an ischaemic event.
National Patent EP21383223, dated 27 December 2021
Title: Circulating miRNAs as predictive biomarkers of cardiovascular disease risk associated with ischaemic events.
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