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Back Extracellular vesicles with improved therapeutic capacity bancodepatentes

Extracellular vesicles with improved therapeutic capacity bancodepatentes

Extracellular vesicles with improved therapeutic capacity bancodepatentes

The invention presents a new generation of a stromal mesenchymal cell line that overexpress HIF-1α and hTERT by genetic modification, which is cultured in the presence of secreted TNF-α, IFN-γ and IL-1β for 48 hours (EVs) with a greater therapeutic potential than those secreted by unenhanced mesenchymal stem cells (MSCs).

These new EVs exert a greater therapeutic effect and in turn allow unlimited cell growth to obtain a stable and homogeneous source of vesicles with improved therapeutic functions. By overexpression of HIF-1α, therapeutic improvement is obtained, while overexpression of hTERT generates unlimited and constant cell division. The main advantage of the invention is the combination in the use of genetic modifications with the specific culture protocol.

INDUSTRIAL PROPERTY RIGHTS

National Patent EP20383170, dated December 29, 2020

FURTHER INFORMATION
Quality of Life: Health Promotion and Efficient Health

CONTACT:
Científico responsable: Dra. Pilar Sepúlveda Sanchis
OTRI IIS La Fe
Instituto de Investigación Sanitaria La Fe
Av. Fernando Abril Martorell, nº 106 46026 Valencia (España)
Contacto: otri@iislafe.es; +34 961 246 609 / +34 618 73 00 95