CLEM microscopy technique. Optical-electron microscopy correlation. - Banco de Patentes

CLEM technique (correlation light electron microscopy) is a combination of the capabilities of two microscopy platforms that normally work separately: optical microscopy (or fluorescence, in this case, FM) and electron microscopy (EM). This combination is used to detect cell dynamic structures and processes in whole cell images with MF and then zoom in for a more detailed view with EM.