Diagnosis and/or prognosis method for Alzheimer disease - Banco de Patentes

This invention is based upon the determination of PS1 heteromeric complexes comprising C-terminal and N-terminal fragments for the diagnosis and/or prognosis of Alzheimer Disease (AD), and therefore is an alternative method for the diagnosis and/or prognosis of AD based upon the use of said heterometric compound.

Besides its applications for early diagnosis and in combination with other markers, the invention will most probably be of great interest for monitoring the progression of the disease and using it in therapy prognosis. In this respect, it is key to highlight how important it is that some of the compounds now under development are γ-secretase activity inhibitors, since it can be very interesting to calculate PS1 levels in patients' CSL in clinical trials with these and other drugs.